In this article, which is part of a broader investigation based on the study of the educational and socio-occupational re-engagement processes of young people in vulnerable situations, the curricular design of the vocational training programs (VTP) is described. Further, the curricular practices developed in the classrooms of these programs are analyzed, based, above all, on how the contents are selected, as well as the methodological approaches for their development. The research methodology that was followed responds to the conduct of multiple case studies with the integration of quantitative and qualitative processes. The data collection instruments used for this purpose were questionnaires, interviews, and discussion groups. The conclusions reveal the selection of contents that are relevant, interesting, and close to the reality of the students. The development of these contents is displayed through varied methodological strategies and diverse activities that enhance the students’ involvement and the practical sense of their learning.